0,2. ??? G ? ??124 96.12 119 99,17 1,32 0,(0,02-1,82) ??3 (OR=3,072; 95% CI 1,914-4,93).

3,? 4 3,10 1 0,83 0,68 0, (0,42-34,57) 1. ? ? / ?? ??

0,GG 1 0,78 0 0,00 0,01 0,????? ? 1994. - ? 283-288.

(0,99-19,08) 2. ? ? ?2-??/ ?0,?252 97,67 231 99,58 2,04 0,? ??? ?, 2003. ? 1.

(0,02-1,48) 3. Abnormal Intracellular Level of Bax in CD3+ Cells 5,from Untreated B-Cell Chronic Lymphocytic Leukemia G 6 2,33 1 0,42 2,04 0,(0,68-47,62) Patients // Laboratory Hematology. 2006. - Vol. 12.

- ?4. - P. 187192.

??? ?4. Bond G.L, Hirshfield K.M, Kirchhoff T. et al.

(-248) G>A ? MDM2 SNP309 accelerates tumor formation in a gen?? GG, der-specific manner // Cancer Res. 2006. Vol. 66.

? ???74,30%, ? P. 10-16.

? ? 46,30% (2=16,245; p=0,001) 5. Leung D.W., Cachianes G., Kuang W.-J., Goeddel (?3).

D.V., Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen // Science. 1989 Vol.

?246. P. 1306-1309.

? ??6. Mathew C.C. The isolation of high molecular ? -248G>A ??weight eucariotic DNA // Methods in Molecular Biol???? ?ogy / Ed. Walker J.M.. - N.Y., L.: Human Press, 1984.

- Vol. 2. - P. 31.

? 7. Phylogenomics of Life-Or-Death Switches in ?(N=108) 2 P OR (95%CI) (N=105) Multicellular Animals: Bcl-2, BH3-Only, and BNip Families of Apoptotic Regulators / ?Aouacheria, F.Brunet, ? % ? % M.Gouy // Molecular Biology and Evolution. 2005.

- Vol. 22. - ?12. - P. 2395-2416.

3,GG 78 74,30 50 46,30 16,24 0,(1,879 - 5,977) 8. Ying-Fang Sun, Jyh-Der Leu, Su-Mei Chen, IFeng Lin and Yi-Jang Lee. Results based on 124 cases 0,GA 23 21,90 41 38,00 5,79 0,of breast cancer and 97 controls from Taiwan suggest (0,251 - 0,84) that the single nucleotide polymorphism (SNP309) in 0,AA 4 3,80 17 15,70 7,23 0,the MDM2 gene promoter is associated with earlier on(0,069 - 0,655) set and increased risk of breast cancer // BMC Cancer.

3, 2009. Vol. 9. P. 13.

G 179 85,20 141 65,30 21,64 0,(1,914 - 4,93) 9. Yuhui Huang, Xiaolan Chen, Mikhail M., Dikov 0,Sergey, Novitskiy V., Claudio A., Mosse, Li Yang, David A 31 14,80 75 34,70 21,64 0,(0,203 - 0,523) P. Carbone Distinct roles of VEGFR-1 and VEGFR-2 in the aberrant hematopoiesis associated with elevated ? ????levels of VEGF // Blood. - 2007. - July 15. Vol. 110(2).

???3 (OR=3,35; 95% P. 624631.

CI 1,88-5,98). , ?GA ?0. Zhang Y., Xiong Y. A p53 amino-terminal nu ? ?, ?? ?clear export signal inhibited by DNA damage-induced ? 38,00% ?21,90% (2=5,79;

phosphorylation // Science. - 2001. Vol. 292 ?

p=0,017). ? ??910-1915.

, , ? ? ? ? ( ) ?? ? ?? ? ?-?? . ?? ?() ? , . ? , ???, 129110, ?, ? , . ? ?61/2, ?: +7 903 629 46 36, e-mail: leo-gann@mail.ru ? ?? ? ?? , ?? ??? ?

?? , ?? ?.

MUCINS EXPRESSION BY STOMACH CARCINOMAS (COMPARATIVE IMMUNOHISTOLOGICAL ANALYSIS) L.E. Gaganov, N.A. Korsakova Vladimirsky Moscow Regional Clinical Scientific and Research Institute The results of the comparative immunohistological research of the mucins expression in the stomach carcinomas developed in forestomachs, in fundic stomach parts, in antrums and in transition zones rtegardless histologocal tumor type are represented in the article.

The key words: mucins, stomach carcinomas, immunohistological expression.

? ?, ?? MUC (MUC), ?? ? ?- [8,10], ??? ? ? ? ? ????? ?. MUC - ???? , - [1,3,5,6,7].

? ? ??? ???[2].

(? MUC1, -5, ?? ? MUC1, 5 ?6 ? ?? - -6 ?-2 ?, ?? ? ???, ?? ? ?? ?? ? ? ?[4].

? ?

? MUC1 ? ???-?? ?, ?? ????? 55 ?? MUC5 ?27-75 ? ?30 ?? ? ?

25 . ? 11 , MUC6 ?, ? ? (? I) 8, ?? ? 9, ? ?? (????? ? II) 10, ? 17. ? ? : Tins 1 ? I 1, II 14, III 39.

MUC2, ?? ?: 12 ? ?

? ? ? ? ??? ? ? 22, ?? 20, - ? 1.

? 1.

? ?? ????ovocastra??KIT ?AKO?(invision, Mouse/Rabbit). ? ? ? ? ?AKO? ? . ? ??? ??. ? 100 ? ?00. ? 4 : I - ? ( 6-25 ), II - (26-50), III - (?50), IV - ? ? 1-5 . ? ?? ? 1. ? ? ? ?????? ??? ? (- ?igmaPlot 11.0???icrosoft Excel? ?12,345 ?6d ?0,055).

??2 ? ????? MUC1, -5, -6 ?-2 ?? (? ?? ? 1000 ? ? ? ).

?(?1). , ?MUC1 (52 ), ? , ?MUC5, -6, ? ???2 (-?37,645, ?3d ?0,001). ? ???, ?MUC5, -6, -2, ?? ?(28, 26 ?25 ? ? , ? ). ? ?M s MUC ?? ?MUC2 (?-? II -? I ? ??MUC5 ?-6 ? 1* 401 551 524 546 446 494 -?0,340, ?2d ?0,844).

5AC** 222 229 7 354 116 186 ?6*** 121 135 6 293 125 136 ?, ?2**** 102 19 2 106 151 76 ??? ? ??77,3 874,6 1732,8 449,9 454,3 - M s MUC ?3 d -? II -? I ? ?<0,001 <0,001 <0,001 <0,001 <0,001 - 16 9 9 7 1 10,4 (n=17) (n=10) (n=9) (n=8) (n=11) ? ?11 6 1 7 5 5,6 ?MUC1, (n=17) (n=10) (n=9) (n=8) (n=11) ? II, 9 5 1 6 6 5,2 ? (??(n=17) (n=10) (n=9) (n=8) (n=11) ?? ? 9 3 1 5 (* -?71, ?4d ?0,001)).

2 5,0 (n=17) (n=10) (n=9) (n=8) (n=11) ?MUC5 ?-MUC6 ? I, ??8,607 7,673 24,000 2,011 13,162 - ? (??3 d ?? ? ?0,035 0,053 <0,001 0,57 0,004 - - (** -?452, ?4d ?0,001 ?*** ?356, ?4d ?0,001 ).

? ?? ? ?MUC2 MUC1 ?? ? ?, ?? ? MUC5, -6 ?-2 ? - (???? ( 1 ). ?? ? (**** -?227, ?? ?

?4d ?0,001).

? ? ? ? ?? Motoshita, N. Oue, H. Nakayama // Japanese Cancer ? ?- Association. 2005. Vol. 96. ?8. P. 474479.

?? ? 2. Gastric Mucus Alterations Associated With ?MUC2, , - Murine Helicobacter Infection / J.M. Schmitz, C.G.

?? ?I ?II , Durham, S.B. Ho, R.G. Lorenz // J. Histochem. Cyto?? ? . ?, chem. 2009. Vol. 57. ?5. P. 457-467.

???? ? 3. Mucin s MUC1, MUC2, MUC5AC and MUC6 ex ? ?TNM. pression in the evaluation of differentiation and clinicobiological behavior of gastric carcinoma / J. Pinto-de Sousa, L. David, A. Reis Celso et al. // Virchows Archiv.

1. ? ?? 2002. Vol. 440. P. 304-310.

??? ????. MUC1 inhibits cell proliferation by a beta-caten? .

in-dependent mechanism / E.P. Lillehoj, W. Lu, T. Kiser 2. ??et al. // Biochim Biophys Acta. 2007. Vol. 1773. ?? MUC1, MUC2.

7. P. 1028-1038.

3. ? ??5. Relationship between immunoexpression of mu ?, ?in peptide cores MUC1 and MUC2 and Laurens his???

tologic subtypes of gastric carcinomas / V. Barresi, E.

4. ??? ?Vitarelli, M. Grosso et al. // Eur. J. Histochem. 2006.

???

Vol. 50. ?4. P. 301-309.

5. ?, ? ?. The Clinicopathological and Prognostic Signifi? cance of MUC-1 Expression in Japanese Gastric Car??? ?cinomas: An Immunohistochemical Study of Tissue ?????Microarrays / X-H. Li, H-C. Zheng, Z-G. Wang et al. // ??( ??, Anticancer Research. 2008. Vol. 28. ?2A. P.

??(?) 1061-1067.

??, ???7. Transmembrane and secreted MUC1 probes show .

trafficking-dependent changes in O-glycan core profiles / K. Engelmann, C.L. Kinlough, S. Mller et al. // Glycobiology. 2005. Vol. 15. ?11. ? 1111-1124.

1. DNA methylation profiles of differentiated-type gastric carcinomas with distinct mucin phenotypes / J.

- ?? , ?? , ?? ?? ?? ? ?? ?? ? ?? ? ?-? -? -? ? -? , . . , ???? ?, 197376, ?, ? ?? . . , 15/17, ?: +7 921 780 37 06, e-mail: toizeg@gmail.com ? in vitro ?? ??? ??? .

?? ?, ? ? .

? ? ? ? HUMAN ALPHA-LACTALBUMIN AND OLEIC ACID COMPLEX PREPARATION V.V. Egorov, M.N. Berlov, A.A. Shaljan, A.V. Vasin, N.A. Grudinina St.Petersburg Institute of Nuclear Physics of Academy of Sciences of Russia Influenza Research Institute of the North West Branch of Academy of Sciences of Russia Environmental Medicine Research Institute The article states the trials succession results of purified human alfa-lactalbumin in vitro complexes and oleic acid which are potentially able to targeted action to tumor cells.

The key words: alfa-lactalbumin, oleic acid, multimeric complexes,anticancer activity.